Mapping QTL in outbred populations using selected samples

QTL Mapping II: Outbred Populations and Association Mapping Mapping in Outbred Populations

Lecture 10 QTL Mapping 2: Outbred Populations

The major difference between QTL analysis using inbred-line crosses vs. outbred populations is that while the parents in the former are genetically uniform, parents in the latter are genetically variable. This distinction has several consequences. First, only a fraction of the parents from an outbred population are informative. For a parent to provide linkage information, it must be heterozygou...

QTL Mapping II: Outbred Populations and Association Mapping

QTL mapping in outbred populations: successes and challenges.

Quantitative trait locus (QTL) mapping in animal populations has been a successful strategy for identifying genomic regions that play a role in complex diseases and traits. When conducted in an F2 intercross or backcross population, the resulting QTL is frequently large, often encompassing 30 Mb or more and containing hundreds of genes. To narrow the locus and identify candidate genes, addition...

Lecture 9 QTL and Association Mapping in Outbred Populations

There are two fundamentally different approaches for mapping QTLs in outbred populations. The first is to look at marker-trait associations in sets of relatives (such as sibs). The second, association mapping, uses collections of unrelated individuals, but requires very dense markers. Both rely on linkage disequilibrium, which is guaranteed in a set of relatives but not certain in a collection ...